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2022 Vol.67, Issue 4 Preview Page

Review Aticle

Pharmacological Effects and Pharmacokinetic Properties of Panax ginseng and Platycodon grandiflorum

인삼과 도라지의 약리적 효과와 약동학적 특성

Sol Jung1
,
Sang Joon An12
,
Yeong In Kim13
,
Hyo Jin Ju14
,
Sang-Yeop Yi15
,
Doo Young Kim16*
정 솔1
,
안 상준12
,
김 영인13
,
주 효진14
,
이 상엽15
,
김 두영16*
1Research Professor, The Convergence Institute of Healthcare and Medical Science, Catholic Kwandong University College of Medicine, Incheon 22711, Korea
2Assistant Professor, Department of Neurology, International St. Mary’s Hospital, Catholic Kwandong University College of Medicine, Incheon 22711, Korea
3Professor, Department of Neurology, International St. Mary’s Hospital, Catholic Kwandong University College of Medicine, Incheon 22711, Korea
4Professor, Department of Medical Humanities, Catholic Kwandong University College of Medicine, Gangwon 25601, Korea
5Professor, Department of Pathology, International St. Mary’s Hospital, Catholic Kwandong University College of Medicine, Incheon 22711, Korea
6Assistant Professor, Department of Rehabilitation Medicine, International St. Mary’s Hospital, Catholic Kwandong University College of Medicine, Incheon 22711, Korea
1가톨릭관동대학교 의과대학 보건의료융합연구소 연구교수
2가톨릭관동대학교 의과대학 국제성모병원 신경과 조교수
3가톨릭관동대학교 의과대학 국제성모병원 신경과 교수
4가톨릭관동대학교 의과대학 의료인문학교실 교수
5가톨릭관동대학교 의과대학 국제성모병원 병리과 교수
6가톨릭관동대학교 의과대학 국제성모병원 재활의학과 조교수
*Corresponding Author
1 December 2022. pp. 305-318
PDF XML Citation
Abstract

To minimize the effects of aging-related comorbidities and to maintain a good quality of life and physical independence for a longer period, the improvement of lifestyle and dietary habits is essential, and healthy foods can be helpful. Among them, medicinal plant such as ginseng (Panax ginseng) and bellflower (Platycodon grandiflorum) contain natural functional substances and have been used for disease treatment and prevention since ancient times. This review summarizes the scientific of these treatments basis by investigating the pharmacological and pharmacokinetic effects of major functional substances on the aging-related health effects of Panax ginseng and Platycodon grandiflorum. The main functional substances of Panax ginseng and Platycodon grandiflorum are saponins, which have a similar molecular structure and confirmed anti-inflammatory, antioxidant, neuroprotective, anticancer, and anti-metabolic syndrome effects (improvement of hypertension, dyslipidemia, diabetes, and obesity). Both types of saponins in Panax ginseng (Ginseonside) and Platycodon grandiflorum (Platycoside) have very low absorption profiles in their purified state, but methods to increase absorption in the body through extraction or fermentation have been studied.

Keywords
Ginsenoside
Panax ginseng
Platycodon grandiflorum
Platycoside
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Information
  • Publisher :The Korean Society of Crop Science
  • Publisher(Ko) :한국작물학회
  • Journal Title :The Korean Journal of Crop Science
  • Journal Title(Ko) :한국작물학회지
  • Volume : 67
  • No :4
  • Pages :305-318
  • Received Date : 2022-08-17
  • Revised Date : 2022-10-06
  • Accepted Date : 2022-10-31
  • DOI :https://doi.org/10.7740/kjcs.2022.67.4.305
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